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TRIAL REGISTRATION : ClinicalTrials. gov NCT00976911. PATIENTS AND METHODS : Eligible patients had measurable/assessable OC that had progressed 6 months after completing platinum-based therapy. Patients with refractory disease, history of bowel obstruction, or two prior anticancer regimens were ineligible. Crossover to single-agent bevacizumab was permitted after progression with chemotherapy alone. The primary end point was progression-free survival (PFS) by RECIST. Secondary end points included objective response rate (ORR overall survival (OS safety, and patient-reported outcomes. RESULTS : The PFS hazard ratio (HR) after PFS events in 301 of 361 patients was 0.48 (95 CI, 0.38 to 0.60; unstratified log-rank P.001). Median PFS was 3.4 months with chemotherapy alone versus 6.7 months with bevacizumab-containing therapy.

RECIST ORR was 11.8 versus 27.3, respectively (P.001). The OS HR was 0.85 (95 CI, 0.66 to 1.08; P.174; median OS, 13.3 v 16.6 months, respectively). Grade 2 hypertension and proteinuria were more common with bevacizumab.

PURPOSE : In platinum-resistant ovarian cancer (OC single-agent chemotherapy is standard. Bevacizumab is active alone and in combination. AURELIA is the first randomized phase III trial to our knowledge combining bevacizumab with chemotherapy in platinum-resistant OC. PATIENTS AND METHODS : Eligible patients had measurable/assessable OC that had progressed 6 months after completing platinum-based therapy. Patients with refractory disease, history of bowel obstruction, or two prior anticancer regimens were ineligible. After investigators selected chemotherapy (pegylated liposomal doxorubicin, weekly paclitaxel, or topotecan patients were randomly assigned to single-agent chemotherapy alone or with bevacizumab (10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks) until progression, unacceptable toxicity, or consent withdrawal. Central Administration 450 Brookline Avenue, BP332A Boston, MA 02215 (617) (877) Toll Free (617) 632-44Farber / Harvard Cancer Center. All rights reserved. TRIAL REGISTRATION : ClinicalTrials. gov NCT00976911. RECIST ORR was 11.8 versus 27.3, respectively (P.001). The OS HR was 0.85 (95 CI, 0.66 to 1.08; P.174; median OS, 13.3 v 16.6 months, respectively). Grade 2 hypertension and proteinuria were more common with bevacizumab. GI perforation occurred in 2.2 of bevacizumab-treated patients. CONCLUSION : Adding bevacizumab to chemotherapy statistically significantly improved PFS and ORR; the OS trend was not significant. No new safety signals were observed. Crossover to single-agent bevacizumab was permitted after progression with chemotherapy alone. The primary end point was progression-free survival (PFS) by RECIST. Secondary end points included objective response rate (ORR overall survival (OS safety, and patient-reported outcomes. While he always remained an ethnic, he felt he had outgrown the old neighborhood. By 1955, when my mother began her career as a school crossing guard at his former elementary school, Lanzas Hollywood career had already peaked, but between 19, he was MGMs biggest box-office attraction. ReturnType: The data type of the return value. Example How to use this example The following example defines a Team class. The Team class includes getter and setter methods that let you retrieve and set properties within the class: package public class Team var teamName:String; var teamCode:String; var teamPlayers:Array new Array public function Team(param_name:String, param_code:String) teamName param_name; teamCode param_code; public function. The following concepts are emphasized: vectors, vector direction, vector addition, vector resolution, vector components, SOHCAHTOA, Pythagorean theorem, equilibrium, statics, weight, tension, two-body problems, pulleys, Atwood machines, inclined plane problems, equilibrium, kinematic equations, friction, and coefficient of friction. Social Media Essay Social The popularity of social networking sites such as Facebook, Twitter, Myspace, and have taken over the world in many ways. Essay on Social Networking. to the users of the social network. Acta Biol. (N.S.). Abraham, A. 1966. The influence of environmental factors on the neurosecretory activity of the water beetle ( Dytiscus marginalis ). Revue Roum. Biol. (Ser. Zool.). Abraham, A. 1966. Differentiating case study techniques from other qualitative approaches, the book discusses concepts, theories, and techniques taken from anthropology, history, sociology, and psychology. Part 2 covers the collection of qualitative data; chapters cover conducting effective interviews, being a careful observer, mining data from documents, and the interactive nature of data collection in case studies. If youre in that position, your decision is probably pretty easy. Theres added value for you to constantly have a newer car, so buying a car on a lease is likely the most effective way to go. GI perforation occurred in 2.2 of bevacizumab-treated patients. CONCLUSION : Adding bevacizumab to chemotherapy statistically significantly improved PFS and ORR; the OS trend was not significant. No new safety signals were observed.

Зелёные бактерии. хлоро-бактерии, микроорганизмы из группы серобактерий, содержащие хлорофилл и усваивающие углекислый газ за счёт солнечной энергии.

After investigators selected chemotherapy (pegylated liposomal doxorubicin, weekly paclitaxel, or topotecan patients were randomly assigned to single-agent chemotherapy alone or with bevacizumab (10 mg/kg every 2 weeks or 15 mg/kg every 3 weeks) until progression, unacceptable toxicity, or consent withdrawal.

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